3-pyridin-3-yl-1H-pyrazole-5-carboxylic acid

3-pyridin-3-yl-1H-pyrazole-5-carboxylic acid - Names and Identifiers

Name	5-pyridin-3-yl-4H-pyrazole-3-carboxylic acid
Synonyms	AKOS PAO-0370 TIMTEC-BB SBB010788 5-(3-pyridyl)-2H-pyrazole-3-carboxylic acid 5-Pyridin-3-Yl-1H-Pyrazole-3-Carboxylic Acid 5-PYRIDIN-3-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID 5-pyridin-3-yl-4H-pyrazole-3-carboxylic acid 5-PYRIDIN-3-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID 3-pyridin-3-yl-1H-pyrazole-5-carboxylic acid 5-(3-Pyridinyl)-1H-pyrazole-3-carboxylic acid 5-(Pyridin-3-yl)-4H-pyrazole-3-carboxylic acid 5-(Pyridin-3-yl)-1H-pyrazole-3-carboxylic acid 4H-pyrazole-3-carboxylic acid, 5-(3-pyridinyl)- 1H-pyrazole-5-carboxylic acid, 3-(3-pyridinyl)- 1H-pyrazole-3-carboxylic acid, 5-(3-pyridinyl)- Acide 5-(3-pyridinyl)-1H-pyrazole-3-carboxylique 3-Carboxy-5-(pyridin-3-yl)-1H-pyrazole, 3-(3-Carboxy-1H-pyrazol-5-yl)pyridine
CAS	374064-01-4
InChI	InChI=1/C9H7N3O2/c13-9(14)8-4-7(11-12-8)6-2-1-3-10-5-6/h1-3,5H,4H2,(H,13,14)

3-pyridin-3-yl-1H-pyrazole-5-carboxylic acid - Physico-chemical Properties

Molecular Formula	C9H7N3O2
Molar Mass	189.17
Density	1.432
Melting Point	308-310℃ (DEC.)
Boling Point	541.4±40.0 °C(Predicted)
Flash Point	194.7°C
Vapor Presure	4.66E-07mmHg at 25°C
pKa	3.56±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.697

3-pyridin-3-yl-1H-pyrazole-5-carboxylic acid - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes.
HS Code	29331990
Hazard Class	IRRITANT

3-pyridin-3-yl-1H-pyrazole-5-carboxylic acid - Introduction

Acid is an organic compound with the chemical formula CFFFFFH NFO2.

Its properties include:
-Appearance: White crystal powder
-Melting point: 200-204°C
-Solubility: Soluble in some organic solvents such as chloroform and dimethyl sulfoxide, insoluble in water

the acid is commonly used in drug research and synthesis. It can be used as a pharmaceutical intermediate for the synthesis of anti-inflammatory, anti-tumor and other bioactive compounds. In addition, it is also used in the preparation of pyrazole heterocyclic compounds.

The method of preparing calcium acid usually includes the following steps:
(1) first reacting pyridine with ethylidene amine to obtain pyridine-3-vinylamine;
(2) reacting the product obtained in step (1) with propanedione in acetic acid to form a pyrazole derivative;
(3) Finally, the acidolysis reaction is carried out with acid to obtain acid.

Regarding safety information, this compound has no special safety risk report under routine operation. However, as a laboratory chemical, general laboratory safety practices should be followed, such as wearing appropriate personal protective equipment (such as gloves, goggles), avoiding contact with skin and eyes, avoiding inhalation of aerosols, and operating in a well-ventilated environment. If accidental contact occurs, rinse immediately with plenty of water and seek medical assistance if necessary.

Last Update：2024-04-09 20:52:54